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Phenibut
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PRODUCT NAME |
Phenibut |
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SHELF LIFE |
2 years |
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ITEM |
SPECIFICATION |
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Appearance |
Almost White Crystal Or Crystalline Powder |
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Assay(Titration) |
99.0% Min |
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Identification |
1.2 Positive |
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Relative material |
0.1% Max |
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Melting point |
194℃～202℃ |
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pH |
2.3～2.7 |
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Clarity of solution |
1# Max |
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Iron |
0.005% Max |
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Loss on drying |
0.5% Max |
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Residue on ignition |
0.1% Max |
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Heavy metals |
10ppm Max |
DESCRIPTION:
Molecular Formula:
C10H13NO2HCl
CAS Registry Number:
1078-21-3
Synonyms：beta-phenyl- gamma-aminobutyric acid, fenibut, phenigamma
Phenibut is a derivative of the neurotransmitter GABA that crosses the blood-brain barrier. It was developed in Russia, and there it has been used clinically since the 1960's for a range of purposes. Phenibut has both nootropic and anxiolytic (anxiety-reducing) properties, and it is commonly compared to diazepam (Valium), baclofen, and piracetam, and it has similarities to and differences from all of these substances.
FUNCTION:
Structurally, phenibut is similar to GABA, baclofen (p-Cl-phenibut), and beta-phenylethylamine (PEA). GABA is the primary inhibitory neurotransmitter in the brain. The addition of the phenyl ring to GABA allows the compound to more easily cross the blood-brain barrier, but also changes its activity profile. Baclofen is a drug commonly used in studies on GABA(B) receptors, and also clinically used to treat severe spasticity of cerebral origin. PEA is a naturally occuring biogenic amine which is similar in structure to amphetamine, and like amphetamine, it is a stimulant that causes the release of dopamine, and also promotes anxiety in high enough amounts.
Phenibut is a GABA receptor agonist and also causes the release of GABA. Similar to baclofen, phenibut is an agonist at GABA(B) receptors, although it does have some effect on GABA(A) receptors as well. It is possible that phenibut has a higher activity at central GABA(B) receptors than peripheral ones. The role of the GABA(B) receptor is not well-established, although research in the last seven years has significantly increased our understanding of this receptor. The most well-established role of GABA(B) receptors is inhibition of the release of some neurotransmitters, and it may also serve as a negative feedback mechanism for GABA release
Because of the structural similarity to PEA, phenibut may share some similarities and differences with it. When phenibut is administered along with PEA, it antagonizes many of its effects, such as promotion of anxiety, promotion of seizures, and hyperthermia. This has lead some to postulate that antagonism of PEA, rather than the GABA-mimetic activity, may be the important mechanism of action for tha anxiolytic effect of phenibut. Phenibut also increases dopamine levels, and it has been postulated that the structural similarity to PEA may play a role in this effect
There is one report in the literature of serotonergic effects of phenibut, but it does not look as though this has been followed up on.
SUGGESTED USE:
Persons on MAOI inhibitors or epilepsy medications like tegretol or trileptal should consult with their psychiatrist / physician prior to supplementation with phenibut. Clinical research has demonstrated that phenibut can potentate or inhibit the function of some epilepsy medications. |
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